Therapeutic Use of KASPER and Urine Drug Screening and Testing in Clinical Practice

Needs Statement

KASPER and UDS/T can be used as therapeutic clinical tools to help monitor for unintended adverse effects of prescribed opioids (and other controlled drugs with known abuse potential and increasing presence in overdose death cases such as the opioids and benzodiazepines) and to help health providers not be unintentional sources of diverted medications. This process can get providers talking more to patients (and their family/friends) about the need for safe storage, diversion, misuse, and substance use disorder that impacts patients and public health.


Target Audience

This activity is designed for prescribers of controlled substances including physicians, nurse practitioners, and dentists and any other interested health care professionals.

Learning Objectives

Upon completion of this educational activity, you will be able to:

  • Interpret and verify a KASPER report
  • Understand how to have appropriate conversations with patients about unexpected KASPER report results 
  • Review metabolism of commonly prescribed pain pills that can affect interpretation of urine drug test and give case examples of common misinterpreted results
  • Explain the differences between urine screens vs. tests

Additional Information

The University of Kentucky College of Medicine
Course summary
Available credit: 
  • 0.75 AMA PRA Category 1 Credit
Course opens: 
Course expires: 

Michelle R. Lofwall, MD, DFASAM
Psychiatry and Behavioral Science
Center on Drug and Alcohol Research
University of Kentucky College of Medicine
Bell Alcohol and Addictions Chair and Medical Director
First Bridge Clinic
UK HealthCare
Lexington, Kentucky


Michelle R. Lofwall, MD, (speaker and planner) has relevant financial relationships with commercial interests as follows:

Orexo, Consultant, Consultant Fee

PCM Scientific, Advisory Board Member, Honorarium

The speaker does not plan to discuss the off-label use of a product.



This activity is jointly provided by the University of Kentucky, Operation UNITE, and Kentucky Office of Drug Control Policy.


This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the University of Kentucky College of Medicine, Operation UNITE, and Kentucky Office of Drug Control Policy. The University of Kentucky College of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

The University of Kentucky College of Medicine designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit(s). Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The University of Kentucky College of Medicine presents this activity for educational purposes only. Participants are expected to utilize their own expertise and judgment while engaged in the practice of medicine. The content of the presentations is provided solely by presenters who have been selected for presentations because of recognized expertise in their field.

This training has been approved by the KBML as meeting the statutory requirements of HB1.

ACGME Competencies

  • Patient care

UK Healthcare CECentral certifies this activity for 0.75 hours of participation.

University of Kentucky College of Public Health certifies that this educational activity was designated for 1.00 hour of Public Health Continuing Education (CPHCE) credit. This course is approved for continuing education by the University of Kentucky College of Public Health.

Available Credit

  • 0.75 AMA PRA Category 1 Credit
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This course is offered through CECentral

To take this course you will be redirected to CECentral's website. You must login or create an account with CECentral in order to complete this activity. 

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