In recent years, there have both been many challenges and advancements in the treatment of ADHD and substance use disorder (SUD) that significantly influence the way advanced practice professionals navigate day-to-day practice. In this program, watch nurse practitioners at the forefront of managing these disorders discuss common obstacles they encounter when prescribing stimulants (e.g., medication shortages, potential for misuse or abuse) and navigate the nuanced differences between the many stimulant formulations for ADHD. From there, shift your focus to the pressing issue of the opioid epidemic as faculty compare the roles, routes of administration, therapeutic impacts, and clinical experience with partial opioid agonists and antagonists to gain valuable insights into managing both SUD and opioid overdose.