How Low Can You Go? The Low-Down on Low Dose Analgesics

Methadone, buprenorphine, and naltrexone are complex medications with a multitude of uses. Perhaps most commonly known for their role in the treatment of opioid use disorder, these medications at low doses have unique utility in pain management. This session will focus on the use of low dose methadone, naltrexone, and microdosing of buprenorphine in pain management. Three experienced clinicians will present rationale, evidence, and best practices on the use of these low-dose strategies.

Learning Objectives

  • Summarize the rationale for microdosing as a strategy for initiation of buprenorphine 
  • Discuss low-dose methadone as an adjuvant analgesic for refractory pain management 
  • Describe the use of low-dose naltrexone as an alternative treatment for chronic pain 
  • Using a patient case, explain principles of unique low-dose management strategies

Additional Information

Tarsus Medical Education
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Course summary
Available credit: 
  • 1.00 AANP Contact Hours
  • 0.70 AANP Pharmacology Contact Hours
  • 1.00 ACPE Pharmacy
  • 1.00 AMA PRA Category 1 Credit
  • 1.00 ANCC
  • 1.00 APA
Course opens: 
Course expires: 

Tanya Uritsky, PharmD, CPE

Opioid Stewardship Coordinator

Hospital of the University of Pennsylvania, Penn Medicine

Philadelphia, PA

Stephanie Abel, PharmD, BCPS

Opioid Stewardship Program Coordinator

UK HealthCare

Lexington, KY

Annabelle Hood, PharmD

Clinical Pharmacy Specialist – Pain Management

Cleveland Clinic

Cleveland, OH


  • Tanya Uritsky – Consulting Fee (e.g., Advisory Board): AcelRx

Available Credit

  • 1.00 AANP Contact Hours
  • 0.70 AANP Pharmacology Contact Hours
  • 1.00 ACPE Pharmacy
  • 1.00 AMA PRA Category 1 Credit
  • 1.00 ANCC
  • 1.00 APA
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