Acute Post-Operative Pain: Current Practice, Novel & Upcoming Analgesic Options, and Drug Development

The ongoing opioid crisis in the US requires clinicians to strike a balance between the benefits of adequate postsurgical analgesia and opioid related risks. This balance is not limited to the immediate postoperative period, but extends to potential prolonged opioid usage. The objectives of postoperative pain management include: (1) efficacious and safe analgesia to minimize suffering while aiming to spare and replace opioids; (2) promoting functional recovery and mobility enabling early discharge; (3) providing options for continued opioid-free regimens at discharge while avoiding a transition from acute to chronic pain. New treatment guidelines and their impact on clinical practice will be critically reviewed. In the search for efficacious non-opioid analgesics with a favorable adverse effect profile, recently approved analgesics for acute pain provide opportunities but may also have drawbacks. For new development candidates, suitable regulatory guidance to support appropriate methods, endpoints, and labeling targets related to reduction or replacement of opioids is required.

Learning Objectives

  • Discuss the difficulties in managing acute pain in the current opioid crisis environment
  • Review enhanced recovery after surgery (ERAS) and effects of opioid sparing after the patient is discharged
  • Outline novel options for the treatment of acute pain recently made available for us in the United States, those that are currently in the later stages of clinical development

Additional Information

Tarsus Medical Education
State Relevance: 
Course summary
Available credit: 
  • 1.00 AANP Contact Hours
  • 1.00 ACPE Pharmacy
  • 1.00 AMA PRA Category 1 Credit
  • 1.00 ANCC
  • 1.00 APA
Course opens: 
Course expires: 

Keith Candiotti, MD
Chair, Department of Anesthesiology
Pain Management and Perioperative Medicine
University of Miami
Miller School of Medicine
Miami, FL

Consulting Fee (e.g., Advisory Board): Acacia, Recro Pharma, Neumentum
Contracted Research (Principal Investigators must provide information, even if received by the institution): Acacia, Pfizer, Merck, Heron


  • 1.00 AANP
  • 1.00 ACCME (All Other)
  • 1.00 ACCME (MD/DO Only)
  • 1.00 ACPE Pharmacy
  • 1.00 ANCC
  • 1.00 APA

Available Credit

  • 1.00 AANP Contact Hours
  • 1.00 ACPE Pharmacy
  • 1.00 AMA PRA Category 1 Credit
  • 1.00 ANCC
  • 1.00 APA
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Pain Management

Opioid Alternatives