The opioid overdose crisis is heading in the wrong direction, with over 81,000 drug overdose deaths in the United States in the 12 months ending in May 2020. Healthcare providers will want to familiarize themselves with MOUD—medication to treat opioid use disorder—as more patients are likely to be prescribed them. Patients coming to the hospital for emergent or planned procedures, or with an acute pain condition, may present unique challenges for the medical team. The patient may have altered nociception thresholds, increased opioid tolerance, and behavioral issues. In order to mitigate complications, it’s important to set clear treatment plans and goals with the patient. This session will cover key principles including the importance of knowing a patient’s history and medication reconciliation including pre-admission planning when possible; optimizing a pain management regimen by providing multimodal analgesia and management of MOUD; coordination of care prior to admission and during discharge planning; treatment planning that includes the patient and providers; and ensuring a safe discharge plan and coordination with ambulatory team.